Titanium Essay -- Biology, Biomaterial, TNA

1.INTRODUCTION Titanium has played a successful biomaterial in biomedical application especially for orthopedics ( uprise-anchoring systems), dentistry, drug delivery, and nano cures in treating get up crabby person and arthritis. One of the interventions of grind away cancer patients is the replacement of cancerous bone with set material. The rate of flow implant materials have implemented coating technology (such as Calcium phosphate or hydroxyapatite) which considers good cytocompatibilty but oer the time it gets encapsulated with the surrounding bone cells and lead to poor osseointegration. An augment of current implant material, we use nanotechnology application tailoring nanoscale topography on conventional implant material into TNA by anodization process. Our aim is to accept the cellular interaction of the cells wedded to the TNA material compared to some(prenominal) selected control material such as hint (pure Titanium without surface modification), glass slides other alloy that commonly been employ as implant material in human. This study is important in order to study whether this material is save from any genotoxicity or oncogenic lay out before been use as human implant material.We have performed several preliminary studies, of the cells culture with TNA compared with control material. The morphology characterization by SEM (Scanning electron Microscope) result shown cells spreading and cytoplasmic extension of cells, but not commensurate to observe neither filipodium nor lamellipodium of the cells cultured on the TNA if compared to the test-control material. We hypotheses these cytoplasmic extensions could penetrate indoors the nanotubes cylindrical-like structure. From this we suggested the TNA topography may assist the protein adsorption and pro... ...both numerical and structural chromosome changes and can give risk to cancer (Stewenius, Y., et al. 2005). 3.4Potential application in cancer treatmentFrom several previous studies have shown, this TNA technology have a authority application in cancer treatment. Mainly in bone cancer treatment, where we can used as implant material to replace the bone lost due to the cancer. Besides study by Enrique Melendez (2002) have account this titania technology have potential as chemotherapeutic agent. Lee, C., et al (2010) also supported Enrique Melendez study, where they concluded that this titania have potential therapeutic application for cancer thermotherapy due to the excellent photothermal properties and high biocompatibility. Therefore our study is important, in order to prove whether the titania is save to be used in this medical treatment application.